Description

N,o-Bis(tert-Butyldimethylsilyl)Acetamide is a specialized organosilicon protecting agent, primarily used for the selective silylation of hydroxyl and amino groups in complex organic synthesis. Its value lies in its high reactivity and steric bulk, which provides excellent regioselectivity and stability of the resulting silyl ethers or amines under a wide range of reaction conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise protection strategies during multi-step syntheses of active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate Synthesis: As a key protecting group reagent for sensitive functional groups (OH, NH) during the multi-step synthesis of complex drug molecules and APIs.
• Peptide Chemistry: For the protection of amino acid side chains (e.g., serine, threonine, tyrosine) in solid-phase and solution-phase peptide synthesis.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products where selective protection/deprotection sequences are critical.
• Agrochemical Research: Used in the development and scale-up of novel pesticides and herbicides that require sophisticated synthetic routes.
• Material Science Precursors: Acts as a silylating agent in the surface modification of silica or other materials, or in the synthesis of silicon-containing polymers.
• Process Chemistry & Scale-Up: Valued in pilot plant and manufacturing settings for its reliability and defined reactivity profile in kilogram-scale reactions.

Basic Information

Product Name	N,o-Bis(tert-Butyldimethylsilyl)Acetamide
CAS No.	82112-21-8
Molecular Formula	C14H33NOSi2
Molecular Weight	287.60 g/mol
Synonyms	N,O-Bis(tert-butyldimethylsilyl)acetamide; N,O-Bis(t-butyldimethylsilyl)acetamide; Acetamide, N,O-bis(1,1-dimethylethyl)dimethylsilyl-; N,O-Bis[(tert-butyldimethylsilyl)]acetamide; BSA (in some contexts, though commonly refers to N,O-Bis(trimethylsilyl)acetamide); tert-Butyldimethylsilyl Acetamide Derivative; TBDMS Acetamide
EINECS	Contact for details

Quality Control

Our N,o-Bis(tert-Butyldimethylsilyl)Acetamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and process development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet the exacting standards of fine chemical synthesis, specifications can be aligned with specific project requirements, including those for cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.