Description

6-Trimethylsilylmethyl-3,4,4A,5,8,8A-Hexahydro-1(2H)-Naphthalenone is a high-value organosilicon intermediate featuring a unique bicyclic ketone structure. This compound is critical for advanced organic synthesis, particularly in constructing complex molecular frameworks for pharmaceuticals and specialty materials. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for its utility as a versatile building block.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the research and development of new generation pesticides and herbicides, leveraging its functionalized naphthalenone core.
• Material Science Research: Acts as a precursor for silicon-containing polymers and advanced organic materials with tailored thermal or optical properties.
• Catalyst Ligand Development: The trimethylsilylmethyl and ketone groups provide handles for developing novel ligands used in asymmetric catalysis.
• Academic & Industrial R&D: A valuable tool compound for methodology development in organic chemistry, including cycloaddition and functionalization reactions.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fragrance molecules and other high-value specialty chemicals.

Basic Information

Product Name	6-Trimethylsilylmethyl-3,4,4A,5,8,8A-Hexahydro-1(2H)-Naphthalenone
CAS No.	82096-10-4
Molecular Formula	C15H26OSi
Molecular Weight	250.45 g/mol
Synonyms	6-((Trimethylsilyl)methyl)-3,4,4a,5,8,8a-hexahydro-1(2H)-naphthalenone; 1(2H)-Naphthalenone, 3,4,4a,5,8,8a-hexahydro-6-[(trimethylsilyl)methyl]-; 6-(Trimethylsilylmethyl)-3,4,4a,5,8,8a-hexahydro-1(2H)-naphthalenone; Hexahydronaphthalenone silyl derivative; TMSM-Hexahydronaphthalenone; Organosilicon naphthalenone intermediate
EINECS	Contact for details

Quality Control

Every batch of 6-Trimethylsilylmethyl-3,4,4A,5,8,8A-Hexahydro-1(2H)-Naphthalenone is produced and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (1H & 13C NMR)
Purity (HPLC/GC)	≥ 95.0% (Typical 97-99%)
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.