Description

(2E)-3-[(4S)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]-2-Methyl-2-Propenoic Acid Ethyl Ester is a high-purity chiral building block and synthetic intermediate of significant value in advanced organic synthesis. Its core utility lies in its stereochemically defined structure, which is essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs), particularly for antiviral, anti-inflammatory, or neurological targets.
• Asymmetric Synthesis: Utilized as a critical building block in stereoselective reactions, including Michael additions, cycloadditions, and cross-coupling reactions, to introduce defined stereocenters.
• Natural Product Synthesis: Serves as a precursor in the total synthesis of natural products and complex macrocycles that require the (S)-configured dioxolane moiety.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, advanced materials, and ligands for catalysis where high enantiomeric purity is required.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of high-value chiral compounds.
• Academic & Industrial Research: A valuable reagent for methodological development in organic chemistry and for exploring new reaction pathways in R&D laboratories.

Basic Information

Product Name	(2E)-3-[(4S)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]-2-Methyl-2-Propenoic Acid Ethyl Ester
CAS No.	81997-76-4
Molecular Formula	C12H20O4
Molecular Weight	228.29 g/mol
Synonyms	Ethyl (2E)-3-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]-2-methyl-2-propenoate; (S)-Ethyl 3-(2,2-Dimethyl-1,3-dioxolan-4-yl)-2-methylacrylate; (S)-Ethyl 2-Methyl-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propenoate; (E)-Ethyl 3-((S)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2-methylacrylate; (2E,4S)-Ethyl 3-(2,2-Dimethyl-1,3-dioxolan-4-yl)-2-methyl-2-propenoate; (S)-2,2-Dimethyl-1,3-dioxolane-4-acrylic acid ethyl ester derivative; Chiral dioxolane acrylate ester
EINECS	Contact for details

Quality Control

Our (2E)-3-[(4S)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]-2-Methyl-2-Propenoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity consistent with pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as oxidizing agents. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.