Description

Dl-2-Amino-8-Phosphonooctanoic Acid is a specialized phosphonic acid derivative that serves as a potent and selective competitive antagonist for the N-methyl-D-aspartate (NMDA) receptor subtype. This compound is a critical research tool for studying excitatory amino acid neurotransmission and neuropharmacology. It is primarily utilized by pharmaceutical researchers, neuroscientists, and biochemical manufacturers in the development and screening of neuroprotective agents and central nervous system (CNS) therapeutics.

Application

• Neuroscience Research: A key pharmacological tool for investigating the role of NMDA receptors in synaptic plasticity, learning, memory, and excitotoxicity.
• Drug Discovery & Development: Used in high-throughput screening assays to identify and characterize novel NMDA receptor antagonists for conditions like stroke, traumatic brain injury, and neurodegenerative diseases.
• Biochemical Standard: Serves as a reference standard in analytical laboratories for method development and quality control of related pharmaceutical compounds.
• Academic & Institutional Research: Employed in university and hospital labs for fundamental studies on glutamate receptor function and neuronal signaling pathways.
• Preclinical Studies: Utilized in animal models to understand the mechanisms of neuropathic pain, epilepsy, and other CNS disorders linked to glutamate excitotoxicity.

Basic Information

Product Name	Dl-2-Amino-8-Phosphonooctanoic Acid
CAS No.	81771-84-8
Molecular Formula	C8H18NO5P
Molecular Weight	239.21 g/mol
Synonyms	DL-AP8; DL-2-Amino-8-phosphonooctanoate; (±)-2-Amino-8-phosphonooctanoic acid; DL-2-Amino-8-phosphono-octanoic acid; AP8; NMDA Receptor Antagonist AP8; Phosphonooctanoic acid derivative; (RS)-2-Amino-8-phosphonooctanoic acid
EINECS	Contact for details

Quality Control

Our Dl-2-Amino-8-Phosphonooctanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Avoid prolonged exposure to air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.