Description

(4R)-2-(3-Hydroxy-2-Pyridyl)-4,5-Dihydro-4-Thiazolecarboxylic Acid is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial interest. Its value lies in its specific stereochemistry and functional groups, which make it a critical precursor in the synthesis of complex, biologically active molecules. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries, particularly those focused on creating novel therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, infectious diseases, and metabolic disorders.
• Agrochemical Synthesis: Serves as a building block for developing new generation pesticides and herbicides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Used in the design of novel chiral ligands and organocatalysts for asymmetric synthesis, improving the yield and enantioselectivity of chemical reactions.
• Chemical Biology Research: Employed as a molecular probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Fine Chemical Production: Integral to the multi-step synthesis of complex fine chemicals and specialty materials requiring high stereochemical purity.

Basic Information

Product Name	(4R)-2-(3-Hydroxy-2-Pyridyl)-4,5-Dihydro-4-Thiazolecarboxylic Acid
CAS No.	81744-98-1
Molecular Formula	C9H8N2O3S
Molecular Weight	224.24 g/mol
Synonyms	(4R)-2-(3-Hydroxy-2-pyridinyl)-4,5-dihydro-4-thiazolecarboxylic acid; (R)-2-(3-Hydroxypyridin-2-yl)-4,5-dihydrothiazole-4-carboxylic acid; 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-, (4R)-; 81744-98-1; (R)-2-(3-Hydroxy-2-pyridyl)-4,5-dihydrothiazole-4-carboxylic acid; (4R)-2-(3-Hydroxy-2-pyridyl)-4,5-dihydrothiazole-4-carboxylic acid; (R)-HPDTCA
EINECS	Contact for details

Quality Control

Our (4R)-2-(3-Hydroxy-2-Pyridyl)-4,5-Dihydro-4-Thiazolecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.