Description

Carbamic Acid, ((2-(Bis(2-Chloroethyl)Amino)Tetrahydro-2H-1,3,2-Oxazap Hosphorin-4-Yl)Oxy)-, Phenylmethyl Ester, p-Oxide CAS NO 81733-40-6 is a specialized organophosphorus compound featuring a complex molecular architecture that combines a carbamate ester with a cyclic oxazaphosphorin moiety. This structure is of significant interest for its potential as a key intermediate in advanced pharmaceutical synthesis, particularly in the development of targeted therapeutic agents. It is primarily sought by research institutions, fine chemical manufacturers, and pharmaceutical R&D departments engaged in creating novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex drug candidates, especially those with alkylating or targeted delivery mechanisms.
• Anticancer Agent Research: Investigated for its potential as a prodrug or active component in experimental oncology research due to its structural similarity to known nitrogen mustard derivatives.
• Biochemical Probe Development: Used in academic and industrial research to study enzyme interactions and biochemical pathways involving phosphorous esters.
• Fine Chemical Synthesis: Employed as a high-value intermediate for constructing sophisticated molecules in custom synthesis and contract manufacturing.
• Agrochemical Research: Potential application in the development of novel pesticides or plant growth regulators, leveraging its bioactive phosphorous core.

Basic Information

Product Name	Carbamic Acid, ((2-(Bis(2-Chloroethyl)Amino)Tetrahydro-2H-1,3,2-Oxazap Hosphorin-4-Yl)Oxy)-, Phenylmethyl Ester, p-Oxide
CAS No.	81733-40-6
Molecular Formula	C₁₇H₂₅Cl₂N₃O₅P
Molecular Weight	462.28 g/mol
Synonyms	Benzyl (2-{bis[2-chloroethyl]amino}-1,3,2-oxazaphosphinan-4-yloxy)carbamate 2-oxide; Cyclophosphamide benzyl carbamate N-oxide; NSC 370955; Benzyl carbamate of 4-hydroxycyclophosphamide; 4-(Benzyloxycarbonylamino)-2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management protocols. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and physical characteristics is provided with each shipment to ensure traceability and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.