Description

Urea, ((2-(Bis(2-Chloroethyl)Amino)Tetrahydro-2H-1,3,2-Oxazaphosphorin -4-Yl)Oxy)-, p-Oxide CAS NO 81732-69-6 is a specialized nitrogen mustard derivative and a key intermediate in advanced pharmaceutical synthesis. This compound is valued for its role in the development of targeted chemotherapeutic agents and other biologically active molecules. It is primarily required by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in oncology drug discovery and the synthesis of complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of nitrogen mustard-based alkylating agents and prodrugs for cancer therapy.
• Oncology Research: Used in biochemical and pharmacological research to study DNA alkylation mechanisms and develop novel anti-cancer compounds.
• Fine Chemical Synthesis: Serves as a precursor for creating complex oxazaphosphorinane derivatives with potential biological activity.
• Bioconjugation Chemistry: Employed in the development of antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Academic Research: Utilized in university and institutional labs for studying the chemistry and reactivity of phosphoramide mustard analogs.
• Process Development: Supports scale-up and optimization studies for the commercial manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Urea, ((2-(Bis(2-Chloroethyl)Amino)Tetrahydro-2H-1,3,2-Oxazaphosphorin -4-Yl)Oxy)-, p-Oxide
CAS No.	81732-69-6
Molecular Formula	C9H19Cl2N3O4P
Molecular Weight	350.15 g/mol
Synonyms	4-(Bis(2-chloroethyl)amino)-2-oxido-1,3,2-oxazaphosphorinane 2-oxide carbamide; Cyclophosphamide Impurity; Cyclophosphamide Related Compound; 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide 4-yl carbamate; Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, 2-[(aminocarbonyl)oxy]tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl ester, P-oxide; Cyclophosphamide Carbamate Derivative; Oxazaphosphorine Mustard Carbamate.
EINECS	Contact for details

Quality Control

Our Urea, ((2-(Bis(2-Chloroethyl)Amino)Tetrahydro-2H-1,3,2-Oxazaphosphorin -4-Yl)Oxy)-, p-Oxide is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.