Description

2-(Trimethylsilyl)Ethyl 1H-Imidazole-2-Carboxylate is a specialized organosilicon-protected imidazole derivative, serving as a crucial building block in advanced organic synthesis. Its value lies in its dual functionality, where the trimethylsilylethyl (TMSE) group acts as a robust yet cleavable protecting group for carboxylic acids, while the imidazole moiety offers versatile reactivity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of complex molecules, heterocyclic compounds, and active pharmaceutical ingredients (APIs) where precise protection-deprotection strategies are required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those containing imidazole or related heterocyclic cores.
• Peptide Synthesis: Used as a protected carboxylic acid derivative in solid-phase and solution-phase peptide chemistry.
• Agrochemical Research: Intermediate in the development of new fungicides, herbicides, and plant growth regulators.
• Material Science: Precursor for functionalized polymers and advanced materials requiring specific imidazole-based ligands or modifiers.
• Organometallic Chemistry: Serves as a ligand or precursor in catalytic systems and metal-organic frameworks (MOFs).
• Academic & R&D Laboratories: A valuable reagent for methodological development in synthetic organic chemistry.

Basic Information

Product Name	2-(Trimethylsilyl)Ethyl 1H-Imidazole-2-Carboxylate
CAS No.	81616-20-8
Molecular Formula	C9H16N2O2Si
Molecular Weight	212.33 g/mol
Synonyms	1H-Imidazole-2-carboxylic acid, 2-(trimethylsilyl)ethyl ester; TMSE-Imidazole-2-carboxylate; 2-(Trimethylsilyl)ethyl imidazole-2-carboxylate; 2-(Trimethylsilyl)ethyl 1H-imidazole-2-carboxylate; 81616-20-8; Imidazole-2-carboxylic acid TMSE ester; 2-(Trimethylsilyl)ethoxycarbonyl imidazole
EINECS	Contact for details

Quality Control

Our 2-(Trimethylsilyl)Ethyl 1H-Imidazole-2-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require storage under an inert atmosphere for long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.