Description

3-Chloro-4-(Trifluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced chemical synthesis. Its unique structure, combining chlorine and trifluoromethyl substituents on the pyridine ring, provides exceptional reactivity and physicochemical properties for creating complex molecules. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical industries seeking to introduce these potent functional groups into target scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials requiring specific halogenated aromatic units.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-Chloro-4-(Trifluoromethyl)Pyridine
CAS No.	81565-19-7
Molecular Formula	C6H3ClF3N
Molecular Weight	181.54 g/mol
Synonyms	3-Chloro-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-3-chloropyridine; 3-Chloro-4-trifluoromethylpyridine; Pyridine, 3-chloro-4-(trifluoromethyl)-; 3-Chloro-α,α,α-trifluoro-4-picoline
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.