Description

3,5-Bis(Trimethylsilyl)Bromobenzene is a high-value organosilicon intermediate featuring bromine and trimethylsilyl functional groups on an aromatic ring. This unique bifunctional structure makes it a versatile and critical building block in advanced organic synthesis, particularly for constructing complex molecular architectures. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require precise and reliable precursors for coupling reactions and functional group manipulations.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring silyl-protected or brominated aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where its functional groups enable specific bioactivity.
• Material Science: Acts as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Organic Synthesis Building Block: Utilized in lithiation and subsequent functionalization reactions, leveraging the directing and stabilizing effects of the trimethylsilyl groups.
• Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating complex organic molecules.

Basic Information

Product Name	3,5-Bis(Trimethylsilyl)Bromobenzene
CAS No.	81500-92-7
Molecular Formula	C12H21BrSi2
Molecular Weight	301.38 g/mol
Synonyms	1-Bromo-3,5-bis(trimethylsilyl)benzene; Benzene, 1-bromo-3,5-bis(trimethylsilyl)-; 3,5-Di(trimethylsilyl)bromobenzene; Bromo-3,5-bis(trimethylsilyl)benzene; 3,5-Bis(trimethylsilyl)-1-bromobenzene; 3,5-Bis(TMS)bromobenzene; 3,5-Bis(trimethylsilyl)phenyl bromide
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trimethylsilyl)Bromobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.