Description

Dexlofexidine is a selective α-2 adrenergic receptor agonist, identified by CAS NO 81447-79-2. This compound is valued for its high pharmacological specificity and serves as a key intermediate in the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D and manufacturing sectors for the development of central nervous system (CNS) agents, sedatives, and analgesic formulations.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel α-2 adrenergic agonists.
• Research & Development: Used in preclinical and clinical studies for investigating sedative, analgesic, and anxiolytic pathways.
• API Synthesis: Key precursor in the manufacturing of finished dosage forms targeting the central nervous system.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.
• Veterinary Medicine: Potential application in the development of sedatives and anesthetic protocols for animals.

Basic Information

Product Name	Dexlofexidine
CAS No.	81447-79-2
Molecular Formula	C9H10Cl2N2
Molecular Weight	217.09 g/mol
Synonyms	Dexlofexidine; (R)-4-[1-(2,3-Dichlorophenyl)ethyl]-1H-imidazole; Lofexidine Impurity; Lofexidine Related Compound; Dexmedetomidine Impurity; α-2 Adrenergic Agonist Intermediate; Dexlofexidine Hydrochloride; BRD-589
EINECS	Contact for details

Quality Control

Our Dexlofexidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.