Description

4-Oxo-1,2-Piperidinedicarboxylic Acid 1-(tert-Butyl) 2-Methyl Ester is a high-purity, protected piperidine derivative that serves as a critical chiral building block and advanced pharmaceutical intermediate. Its value lies in its role as a versatile synthon for constructing complex nitrogen-containing heterocycles, enabling the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new therapeutic agents and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting neurological and metabolic disorders.
• Chiral Building Block: Used in asymmetric synthesis to introduce the piperidine scaffold with defined stereochemistry into target molecules.
• Protease Inhibitor Research: Serves as a core structural element in the development of novel protease inhibitors for antiviral and anticancer therapies.
• Agrochemical Synthesis: Employed in the creation of advanced herbicides and pesticides with specific modes of action.
• Ligand and Catalyst Development: Utilized for constructing novel chiral ligands and organocatalysts for use in enantioselective transformations.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new chemical space in medicinal chemistry programs.

Basic Information

Product Name	4-Oxo-1,2-Piperidinedicarboxylic Acid 1-(tert-Butyl) 2-Methyl Ester
CAS No.	81357-18-8
Molecular Formula	C13H21NO5
Molecular Weight	271.31 g/mol
Synonyms	1-(tert-Butyl) 2-methyl 4-oxopiperidine-1,2-dicarboxylate; 1-Boc-2-methyl 4-oxopiperidine-1,2-dicarboxylate; 4-Oxo-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester; tert-Butyl methyl 4-oxopiperidine-1,2-dicarboxylate; 1-N-Boc-4-oxopipecolic acid methyl ester; Methyl 1-(tert-butoxycarbonyl)-4-oxopiperidine-2-carboxylate; 4-Oxo-1,2-piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-methyl ester
EINECS	Contact for details

Quality Control

Our 4-Oxo-1,2-Piperidinedicarboxylic Acid 1-(tert-Butyl) 2-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from strong acids and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.