Description

[3As-(3A,4,5,6A)]-(9Ci)-4-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Hexahydro-5-Hydroxy-2(1H)-Pentalenone CAS NO 81266-61-7 is a high-purity, protected synthetic intermediate characterized by its complex, functionalized pentalenone core. This compound is of significant value in advanced organic synthesis, particularly for constructing intricate molecular architectures where precise stereochemistry and functional group manipulation are critical. It is primarily sought after by research institutions and pharmaceutical development teams engaged in the synthesis of novel active pharmaceutical ingredients (APIs), complex natural products, and specialized fine chemicals.

Application

This protected hydroxy pentalenone serves as a versatile and critical building block in sophisticated chemical synthesis. Its primary applications include:

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and novel therapeutic agents.
• Natural Product Synthesis: Used in the total or semi-synthesis of complex natural products with biological activity, leveraging its intricate fused-ring structure.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce chiral centers into target molecules due to its defined stereochemistry.
• Medicinal Chemistry Research: Utilized for structure-activity relationship (SAR) studies and the exploration of new chemical entities in drug discovery programs.
• Advanced Material Science: Potential use as a monomer or precursor for specialized polymers and functional materials requiring specific molecular geometries.
• Process Chemistry Development: Serves as a model compound for developing and optimizing scalable synthetic routes in pilot and kilo-lab settings.

Basic Information

Item	Details
Product Name	[3As-(3A,4,5,6A)]-(9Ci)-4-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Hexahydro-5-Hydroxy-2(1H)-Pentalenone
CAS No.	81266-61-7
Molecular Formula	C16H30O3Si
Molecular Weight	298.50 g/mol
Synonyms	4-[[(tert-Butyldimethylsilyl)oxy]methyl]hexahydro-5-hydroxy-2(1H)-pentalenone; TBDMS-protected Hydroxy Pentalenone; (3aR,4S,5R,6aS)-4-(((tert-Butyldimethylsilyl)oxy)methyl)hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-one; tert-Butyldimethylsilyl Ether of Hydroxymethyl Pentalenone; Protected Pentalenone Derivative; CAS 81266-61-7
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.