Description

Acetyllovastatin is a key pharmaceutical intermediate and a derivative of the statin class of compounds. It is primarily utilized in the research and development of cholesterol-lowering agents, serving as a crucial precursor in synthetic pathways. This high-purity compound is essential for pharmaceutical manufacturers, research institutions, and fine chemical suppliers focused on cardiovascular drug development and metabolic disorder research.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced statin-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in biochemical and pharmacological studies to investigate HMG-CoA reductase inhibition and cholesterol metabolism.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Process Chemistry: Employed in the development and scale-up of novel synthetic routes for cardiovascular drugs.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) within the statin family.

Basic Information

Product Name	Acetyllovastatin
CAS No.	81189-92-6
Molecular Formula	C26H36O6
Molecular Weight	444.56 g/mol
Synonyms	Acetyl Lovastatin; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate; 2-Methylbutyric Acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester; Lovastatin Acetate; Monacolin K Acetate
EINECS	Contact for details

Quality Control

Our Acetyllovastatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via IR and NMR, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.