Description

4-tert-Butyl-2-Chloropyridine is a versatile halogenated pyridine derivative, serving as a crucial building block in advanced organic synthesis. Its value lies in the combination of the electron-donating tert-butyl group and the reactive chlorine atom, which facilitates selective functionalization. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides and herbicides, where the pyridine core is a common structural motif.
• Ligand Precursor: Acts as a starting material for the synthesis of specialized ligands used in catalysis and material science.
• Functional Material Research: Employed in the creation of organic electronic materials, liquid crystals, and photoactive compounds.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl structures.
• Nucleophilic Substitution: The chlorine atom is readily displaced by various nucleophiles (amines, alkoxides) to introduce diverse functionality.

Basic Information

Product Name	4-tert-Butyl-2-Chloropyridine
CAS No.	81167-60-4
Molecular Formula	C9H12ClN
Molecular Weight	169.65 g/mol
Synonyms	2-Chloro-4-tert-butylpyridine; 4-(tert-Butyl)-2-chloropyridine; 2-Chloro-4-(1,1-dimethylethyl)pyridine; 4-tert-Butyl-2-chloropyridine; 2-Chloro-4-(tert-butyl)pyridine; Pyridine, 2-chloro-4-(1,1-dimethylethyl)-; 4-(tert-Butyl)-2-chloro-pyridine
EINECS	Contact for details

Quality Control

Our 4-tert-Butyl-2-Chloropyridine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP and ISO standards for reliable, batch-to-batch consistency in critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.