Description

Cyclopropyl(Trimethylsilyl)Acetylene is a versatile organosilicon building block featuring both a cyclopropyl ring and a protected acetylene (alkyne) functionality. This compound is highly valued in synthetic organic chemistry for its role as a key intermediate in constructing complex molecular architectures. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in cross-coupling reactions, cycloadditions, and the synthesis of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing cyclopropane or alkyne motifs with potential biological activity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the cyclopropyl group can enhance stability and efficacy.
• Material Science Precursor: Serves as a monomer or building block for advanced polymers, dendrimers, and functionalized surfaces with tailored properties.
• Cross-Coupling Reactions: Employed in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to introduce the cyclopropylacetylene unit into complex molecules.
• Cycloaddition Chemistry: Acts as a dienophile or dipolarophile in [2+2], [3+2], and other cycloaddition reactions to form novel carbocyclic and heterocyclic systems.
• Ligand and Catalyst Development: Utilized to create sophisticated ligands for asymmetric catalysis or functionalize catalytic surfaces.

Basic Information

Product Name	Cyclopropyl(Trimethylsilyl)Acetylene
CAS No.	81166-84-9
Molecular Formula	C8H14Si
Molecular Weight	138.28 g/mol
Synonyms	((Cyclopropyl)ethynyl)trimethylsilane; Trimethyl((cyclopropylethynyl))silane; Cyclopropylethynyltrimethylsilane; TMS-Cyclopropylacetylene; (Cyclopropylethynyl)trimethylsilane; 1-Trimethylsilyl-1-cyclopropylacetylene; Silane, ((cyclopropylethynyl)trimethyl-
EINECS	Contact for details

Quality Control

Our production of Cyclopropyl(Trimethylsilyl)Acetylene adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed via GC, NMR, and other appropriate analytical techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its moisture-sensitive (hygroscopic) nature, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.