Description

1'-Benzylspiro[Isochroman-1,4'-Piperidine] Hydrochloride is a high-purity organic compound belonging to the spirocyclic piperidine class, valued for its role as a sophisticated chemical intermediate. This compound is critical for research and development in advanced pharmaceutical synthesis, particularly for creating novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing central nervous system (CNS) and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting neurological pathways.
• Chemical Research & Development: Used as a core scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Employed in university and institutional labs for studying spirocyclic compound chemistry and pharmacology.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1'-Benzylspiro[Isochroman-1,4'-Piperidine] Hydrochloride
CAS No.	81109-64-0
Molecular Formula	C20H23NO • HCl
Molecular Weight	329.87 g/mol (Free base: 293.41 g/mol)
Synonyms	Spiro[isochroman-1,4'-piperidine], 1'-benzyl-, hydrochloride; 1'-Benzylspiro[isochromane-1,4'-piperidine] HCl; 1'-Benzyl-1,4-dihydrospiro[isochromene-3,4'-piperidine] hydrochloride; Benzylspiroisochromanpiperidine HCl; 81109-64-0; UNII-4P0K2QJ9QN; 4P0K2QJ9QN
EINECS	Contact for details

Quality Control

Our 1'-Benzylspiro[Isochroman-1,4'-Piperidine] Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. Certificates of Analysis (COA) documenting full specifications are provided to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.