Description

L-Proline, 4-Hydroxy-, Methyl Ester, (4S)- (9Ci) is a chiral, non-proteinogenic amino acid derivative of significant synthetic utility. This compound serves as a crucial building block and intermediate in the synthesis of complex bioactive molecules, particularly in pharmaceutical research. It is essential for R&D chemists and process development scientists working in pharmaceutical, peptide synthesis, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of protease inhibitors, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce modified proline residues, influencing peptide conformation and stability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective reactions to construct complex molecular architectures.
• Biochemical Research: Serves as a substrate or inhibitor analog in enzymatic studies, particularly those involving proline hydroxylases and related enzymes.
• Fine Chemical Production: Intermediate in the manufacture of specialty chemicals, flavors, fragrances, and advanced materials.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in organic and medicinal chemistry.

Basic Information

Product Name	L-Proline, 4-Hydroxy-, Methyl Ester, (4S)- (9Ci)
CAS No.	81102-38-7
Molecular Formula	C7H11NO4
Molecular Weight	173.17 g/mol
Synonyms	(4S)-4-Hydroxy-L-proline methyl ester; Methyl (4S)-4-hydroxypyrrolidine-2-carboxylate; Methyl L-4-hydroxyprolinate; 4-Hydroxy-L-proline methyl ester; (2S,4S)-4-Hydroxy-2-pyrrolidinecarboxylic acid methyl ester; 4-Hydroxyproline methyl ester; L-4-Hydroxyproline methyl ester; trans-4-Hydroxy-L-proline methyl ester
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Hydroxy-, Methyl Ester, (4S)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the stringent requirements for research and development applications. Certificates of Analysis (COA) documenting identity, purity, and specific properties are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.