Description

Pravastatin CAS NO 81093-37-0 is a potent, competitive inhibitor of HMG-CoA reductase, a key enzyme in the cholesterol biosynthesis pathway. This high-purity active pharmaceutical ingredient (API) is critical for the formulation of safe and effective cholesterol-lowering medications. It is primarily required by pharmaceutical manufacturers for the production of solid oral dosage forms, such as tablets, to treat hypercholesterolemia and prevent cardiovascular disease.

Application

• Pharmaceutical API: Primary use as the active ingredient in cholesterol-lowering tablets and other oral formulations.
• Hypercholesterolemia Treatment: Formulated into medications that effectively reduce LDL ("bad") cholesterol and triglyceride levels in the blood.
• Cardiovascular Disease Prevention: Used in drugs aimed at lowering the risk of heart attack, stroke, and related cardiovascular events.
• Generic Drug Manufacturing: Serves as a key component for producers of generic pravastatin sodium medications.
• Research & Development: Utilized in preclinical and clinical studies for developing new lipid-regulating therapies or combination drugs.
• Reference Standard: High-purity grades can be used as analytical reference standards in quality control laboratories.

Basic Information

Product Name	Pravastatin
CAS No.	81093-37-0
Molecular Formula	C₂₃H₃₅NaO₇
Molecular Weight	446.52 g/mol
Synonyms	Pravastatin Sodium; SQ 31,000; Pravachol; Elisor; Lipostat; Selektine; (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-Hydroxy-2-methyl-8-[(S)-2-methylbutyryloxy]-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid Sodium Salt; Sodium Pravastatin
EINECS	Contact for details

Quality Control

Our Pravastatin is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use, with specifications typically aligned with major pharmacopoeias such as USP and EP. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Complies with EP/USP

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.