Description

(2-Naphthoxy)Acetic Acid n-Hydroxysuccinimide Ester is a high-purity, reactive chemical intermediate designed for advanced synthesis. This compound is a critical building block for creating amide bonds under mild conditions, offering superior efficiency and selectivity in conjugation reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing novel active compounds and functionalized polymers.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs via amide coupling.
• Bioconjugation: Used for labeling proteins, peptides, and antibodies with fluorescent dyes, drugs, or other functional molecules in diagnostic and therapeutic development.
• Polymer Functionalization: Enables the modification of polymer backbones to introduce specific bioactive or chemical groups for advanced material science applications.
• Peptide Synthesis: Acts as an efficient coupling agent in solid-phase and solution-phase peptide synthesis to form peptide bonds.
• Linker Chemistry: Serves as a versatile linker in the construction of drug delivery systems, such as antibody-drug conjugates (ADCs).
• Research & Development: Essential tool compound in organic and medicinal chemistry labs for exploring new synthetic pathways and molecular entities.

Basic Information

Product Name	(2-Naphthoxy)Acetic Acid n-Hydroxysuccinimide Ester
CAS No.	81012-92-2
Molecular Formula	C₁₇H₁₅NO₅
Molecular Weight	313.31 g/mol
Synonyms	2-Naphthoxyacetic Acid N-Hydroxysuccinimide Ester; NHS Ester of 2-Naphthoxyacetic Acid; N-Hydroxysuccinimide 2-Naphthoxyacetate; 2-(Naphthalen-2-yloxy)acetic Acid 2,5-Dioxopyrrolidin-1-yl Ester; 2-Naphthyloxyacetic Acid Succinimidyl Ester; N-(2-Naphthoxyacetyloxy)succinimide; NOA-NHS; 81012-92-2
EINECS	Contact for details

Quality Control

Our (2-Naphthoxy)Acetic Acid n-Hydroxysuccinimide Ester is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to meet the stringent requirements of research and cGMP manufacturing environments. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.