Description

cis-1-(4-Fluorophenyl)-4-[1-(4-Fluorophenyl)-4-Oxo-1,3,8-Triazaspiro[4.5]Dec-8-Yl]Cyclohexanecarbonitrile is a complex, high-value pharmaceutical intermediate featuring a unique spirocyclic triaza structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and advanced fine chemical manufacturers seeking to develop new drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, especially those with spirocyclic architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Protease Inhibitor Development: Its structural motifs are relevant for the research and development of enzyme inhibitors.
• Ligand Synthesis for Receptor Studies: Employed in creating novel ligands for pharmacological profiling and receptor binding assays.
• Advanced Organic Synthesis: Acts as a sophisticated precursor for constructing complex heterocyclic compounds in academic and industrial research.
• Pre-clinical Drug Development: Supplied for use in the synthesis of compounds for in vitro and in vivo biological testing.

Basic Information

Item	Details
Product Name	cis-1-(4-Fluorophenyl)-4-[1-(4-Fluorophenyl)-4-Oxo-1,3,8-Triazaspiro[4.5]Dec-8-Yl]Cyclohexanecarbonitrile
CAS No.	80912-78-3
Molecular Formula	C26H28F2N4O
Molecular Weight	450.53 g/mol
Synonyms	cis-1-(4-Fluorophenyl)-4-[1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]cyclohexanecarbonitrile; 1,3,8-Triazaspiro[4.5]decane-8-acetonitrile, 1-(4-fluorophenyl)-4-oxo-4-[4-(4-fluorophenyl)-4-cyanocyclohexyl]-; 80912-78-3; UNII-9F8S9Q4J0V; 9F8S9Q4J0V; Spirocyclic Triaza Compound; 4-Fluorophenyl Spiro Triaza Carbonitrile
EINECS	Contact for details

Quality Control

Our cis-1-(4-Fluorophenyl)-4-[1-(4-Fluorophenyl)-4-Oxo-1,3,8-Triazaspiro[4.5]Dec-8-Yl]Cyclohexanecarbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, generated using validated analytical methods such as HPLC, NMR, and MS. We support cGMP compliance for advanced intermediates and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.