Description

Dimethyl (4-Hydroxyphenyl)Malonate is a versatile aromatic malonate ester derivative, serving as a key synthetic intermediate in advanced organic synthesis. Its molecular structure, featuring both a phenolic hydroxyl group and a reactive malonate moiety, makes it a valuable building block for constructing complex molecules. This compound is particularly relevant for research and production in the pharmaceutical and fine chemical sectors, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds with phenolic or benzofuran backbones.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators that require specific aromatic ester functionalities.
• Fine Chemical Production: Serves as a building block for dyes, pigments, and specialty polymers where controlled introduction of a hydroxyphenyl group is necessary.
• Liquid Crystal & OLED Material Research: Employed in the synthesis of organic electronic materials due to its ability to modify molecular polarity and conjugation.
• Flavor & Fragrance Industry: Acts as an intermediate for creating complex aromatic esters used in high-value fragrance compositions.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry, including cross-coupling and condensation reactions.

Basic Information

Item	Details
Product Name	Dimethyl (4-Hydroxyphenyl)Malonate
CAS No.	80887-78-1
Molecular Formula	C11H12O5
Molecular Weight	224.21 g/mol
Synonyms	Dimethyl 4-Hydroxyphenylmalonate; (4-Hydroxyphenyl)propanedioic Acid Dimethyl Ester; Dimethyl (p-Hydroxyphenyl)malonate; Propanedioic acid, (4-hydroxyphenyl)-, 1,3-dimethyl ester; p-Hydroxyphenylmalonic Acid Dimethyl Ester
EINECS	Contact for details

Quality Control

Our Dimethyl (4-Hydroxyphenyl)Malonate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results for parameters including assay, related substances, and residual solvents, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.