Description

3-(Trimethylsilylethynyl)Pyridine is a specialized organosilicon building block featuring a pyridine ring linked to a trimethylsilyl-protected acetylene group. This unique structure makes it a valuable intermediate for constructing complex molecular architectures in advanced materials and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as click chemistry, cross-coupling reactions, and the synthesis of functionalized ligands.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring acetylene or pyridine motifs.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its reactivity for creating diverse chemical structures.
• Material Science & Polymer Chemistry: Serves as a monomer or functionalizing agent in the development of conductive polymers, metal-organic frameworks (MOFs), and advanced organic electronic materials.
• Cross-Coupling Reactions: An effective reagent in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand Synthesis: Used to prepare sophisticated ligands for catalysis, including those for asymmetric synthesis and transition metal complexes.
• Click Chemistry: The protected acetylene group can be deprotected for use in Huisgen 1,3-dipolar cycloaddition (azide-alkyne click chemistry) reactions.

Basic Information

Product Name	3-(Trimethylsilylethynyl)Pyridine
CAS No.	80673-00-3
Molecular Formula	C10H13NSi
Molecular Weight	175.31 g/mol
Synonyms	3-[(Trimethylsilyl)ethynyl]pyridine; 3-(2-Trimethylsilylethynyl)pyridine; Pyridine, 3-[(trimethylsilyl)ethynyl]-; 3-Ethynylpyridine, trimethylsilyl derivative; 3-(Trimethylsilylethynyl)pyridine; TMS-Ethynylpyridine
EINECS	Contact for details

Quality Control

Our 3-(Trimethylsilylethynyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.