Description

Boc-Sar-Osu CAS NO 80621-90-5 is a specialized N-hydroxysuccinimide (NHS) ester derivative of the protected amino acid sarcosine (Sar). This compound is a critical reagent in peptide synthesis and bioconjugation chemistry, serving as an efficient coupling agent for introducing the Boc-protected sarcosine moiety. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and life sciences sectors for the development of novel peptides, prodrugs, and modified biomolecules, ensuring high coupling yields and minimal racemization.

Application

• Peptide Synthesis: A key building block for the solid-phase and solution-phase incorporation of sarcosine into custom peptide sequences.
• Bioconjugation & Linker Chemistry: Used to attach Boc-protected sarcosine to amines on proteins, antibodies, or other biomolecules for creating stable amide bonds.
• Prodrug Development: Facilitates the synthesis of peptide-based prodrugs where sarcosine acts as a biodegradable linker.
• Chemical Biology Research: Enables the study of protein structure-function relationships and the creation of chemically modified peptides for assay development.
• Material Science: Employed in the surface functionalization of polymers and nanomaterials with bioactive peptide motifs.
• Intermediate for Fine Chemicals: Serves as a high-purity intermediate in the multi-step synthesis of complex organic molecules and active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Boc-Sar-Osu
CAS No.	80621-90-5
Molecular Formula	C12H18N2O6
Molecular Weight	286.28 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-methylglycine N-hydroxysuccinimide ester; Boc-N-methylglycine-OSu; Boc-Sarcosine-OSu; Boc-Sar-OSu; (2,5-Dioxopyrrolidin-1-yl) 2-[(tert-butoxycarbonyl)(methyl)amino]acetate; 2-[(tert-Butoxycarbonyl)(methyl)amino]acetic acid 2,5-dioxopyrrolidin-1-yl ester; N-(tert-Butoxycarbonyl)sarcosine N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Every batch of Boc-Sar-Osu is manufactured and tested under strict quality management systems to ensure consistency and reliability for critical research and production applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.