Description

3-Pyrrolidineacetic Acid, Hydrochloride is a versatile heterocyclic building block and chiral intermediate of significant importance in modern synthetic chemistry. Its pyrrolidine core, functionalized with an acetic acid moiety, makes it a valuable precursor for the development of pharmacologically active compounds and fine chemicals. This high-purity material is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to synthesize complex molecules with specific stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) agents, enzyme inhibitors, and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators that require specific stereochemical configurations for optimal activity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity in chemical reactions.
• Peptidomimetics Research: The pyrrolidine structure is a common scaffold in peptidomimetics, making this compound valuable for designing novel protease inhibitors and bioactive peptide analogs.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, flavors, fragrances, and advanced materials where precise molecular architecture is required.

Basic Information

Product Name	3-Pyrrolidineacetic Acid, Hydrochloride
CAS No.	80616-50-8
Molecular Formula	C6H11NO2 • HCl
Molecular Weight	165.62 g/mol (Free base: 129.16)
Synonyms	3-Pyrrolidineacetic acid hydrochloride; (3-Pyrrolidinyl)acetic acid hydrochloride; 1-(Carboxymethyl)pyrrolidin-3-amine hydrochloride; 3-Aminopyrrolidine-1-acetic acid hydrochloride; Pyrrolidine-3-acetic acid, hydrochloride; NSC 403914; 80616-50-8
EINECS	Contact for details

Quality Control

Our 3-Pyrrolidineacetic Acid, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (typical)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.