Description

Triisopropylsilyl Trifluoromethanesulfonate is a highly reactive organosilicon reagent, specifically a silyl triflate. This compound is a powerful silylating agent, valued for its ability to introduce the bulky triisopropylsilyl (TIPS) protecting group onto oxygen and nitrogen nucleophiles under mild conditions. It is an essential intermediate in the synthesis of complex organic molecules, particularly in pharmaceutical research and fine chemical production. Industries requiring advanced organic synthesis, such as agrochemicals, materials science, and academic R&D, rely on its consistent performance and purity.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key protecting group reagent in multi-step syntheses of active pharmaceutical ingredients (APIs), particularly for sensitive alcohols and phenols.
• Nucleoside and Carbohydrate Chemistry: Essential for the selective protection of hydroxyl groups in the synthesis of nucleosides, nucleotides, and complex sugars.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products where robust, orthogonal protecting group strategies are required.
• Polymer and Material Science: Acts as a functionalization agent or initiator in the development of specialty silicon-containing polymers and advanced materials.
• Agrochemical Research: Utilized in the synthesis of novel herbicide and pesticide candidates that require selective silylation steps.
• Process Chemistry Development: Serves as a reagent for optimizing scalable synthetic routes in fine chemical manufacturing.

Basic Information

Item	Details
Product Name	Triisopropylsilyl Trifluoromethanesulfonate
CAS No.	80522-42-5
Molecular Formula	C10H21F3O3SSi
Molecular Weight	306.42 g/mol
Synonyms	Triisopropylsilyl Triflate; TIPS Triflate; Triisopropylsilyl Trifluoromethanesulfonate; Trifluoromethanesulfonic Acid Triisopropylsilyl Ester; TIPSOTf; (Triisopropylsilyl) Trifluoromethanesulfonate; 1,1,1-Trifluoro-N-(triisopropylsilyl)methanesulfonamide (alternative naming); Triisopropylsilyl ester of trifluoromethanesulfonic acid
EINECS	Contact for details

Quality Control

Our Triisopropylsilyl Trifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F), HPLC for purity assessment, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (argon or nitrogen) when not in use. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.