Description

1-Phenylethanone o-(Trimethylsilylmethyl)Oxime is a specialized organosilicon compound featuring a silyl-protected oxime functional group. This unique structure makes it a valuable synthetic intermediate and building block in advanced organic synthesis, particularly for introducing nitrogen and silicon functionalities. It is primarily utilized by pharmaceutical and agrochemical research and development teams for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring silyl-protected functional groups.
• Agrochemical Synthesis: Used as a building block for developing advanced crop protection agents and herbicides.
• Organometallic Chemistry: Serves as a ligand or precursor in catalytic systems and metal-organic framework (MOF) research.
• Material Science Research: Employed in the development of silicon-based polymers and advanced functional materials.
• Organic Synthesis Reagent: Facilitates the formation of C-N bonds and acts as a masked carbonyl equivalent in multi-step synthetic routes.
• Academic & Industrial R&D: A valuable tool for chemists in discovery chemistry and process development for fine chemicals.

Basic Information

Product Name	1-Phenylethanone o-(Trimethylsilylmethyl)Oxime
CAS No.	80496-47-5
Molecular Formula	C₁₂H₁₉NOSi
Molecular Weight	221.37 g/mol
Synonyms	Acetophenone O-[(Trimethylsilyl)methyl]oxime; O-[(Trimethylsilyl)methyl]acetophenone oxime; α-(Trimethylsilylmethyl)oxime of Acetophenone; (Trimethylsilylmethyl) Acetophenone Oxime; TMSM-Acetophenone Oxime; 1-Phenylethanone, O-[(trimethylsilyl)methyl]oxime; Acetophenone O-(trimethylsilylmethyl)oxime
EINECS	Contact for details

Quality Control

Our production of 1-Phenylethanone o-(Trimethylsilylmethyl)Oxime adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analysis, including HPLC for assay and impurity profiling, NMR for structural confirmation, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.