Description

[1,1'-Biphenyl]-2-Carboxylic Acid, 4'-Fluoro-, Methyl Ester is a high-purity fluorinated biphenyl derivative, serving as a critical advanced pharmaceutical intermediate and versatile organic synthesis building block. Its unique structure, featuring a biphenyl core with a fluorine substituent and a methyl ester group, makes it indispensable for constructing complex molecules in medicinal chemistry. This compound is primarily utilized by R&D scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, where the fluorinated biphenyl moiety can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor or core structure in the development of fluorinated liquid crystals and organic light-emitting diode (OLED) materials for electronic displays.
• Organic Ligand Synthesis: Utilized to create specialized ligands for catalysis and metal-organic frameworks (MOFs), leveraging its rigid biphenyl structure.
• Polymer Modification: Acts as a monomer or additive to introduce fluorine and aromatic character into polymers, potentially improving thermal stability and chemical resistance.
• Academic & Industrial R&D: Employed in research laboratories for method development, structure-activity relationship (SAR) studies, and exploring new chemical spaces.

Basic Information

Product Name	[1,1'-Biphenyl]-2-Carboxylic Acid, 4'-Fluoro-, Methyl Ester
CAS No.	80254-82-6
Molecular Formula	C15H13FO2
Molecular Weight	244.26 g/mol
Synonyms	4'-Fluoro-2-biphenylcarboxylic Acid Methyl Ester; Methyl 4'-Fluoro[1,1'-biphenyl]-2-carboxylate; 2-(4-Fluorophenyl)benzoic Acid Methyl Ester; 4'-Fluoro-2-phenylbenzoic Acid Methyl Ester; Methyl 2-(4-Fluorophenyl)benzoate; Biphenyl-2-carboxylic Acid, 4'-Fluoro-, Methyl Ester; 2-Carbomethoxy-4'-fluorobiphenyl
EINECS	Contact for details

Quality Control

Our production of [1,1'-Biphenyl]-2-Carboxylic Acid, 4'-Fluoro-, Methyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical synthesis workflows. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via NMR and MS. We provide detailed Certificates of Analysis (COA) with all shipments, documenting key specifications to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.