Description

3-Chloro-1H-Pyrrolo[2,3-B]Pyridine is a versatile and high-value heterocyclic building block, primarily used in advanced pharmaceutical research and development. This compound is critical for medicinal chemists seeking to develop novel small-molecule therapeutics, particularly in oncology and central nervous system (CNS) drug discovery. Its unique fused pyrrolopyridine scaffold, functionalized with a reactive chlorine atom, makes it an essential intermediate for constructing complex molecular architectures. Key industries that rely on this high-purity intermediate include pharmaceutical R&D, contract research organizations (CROs), and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of kinase inhibitors and other targeted cancer therapies.
• Agrochemical Research: Used in the development of novel active ingredients for crop protection.
• Material Science: Serves as a precursor for organic electronic materials and ligands in catalysis.
• Academic & Contract Research: A valuable building block for medicinal chemistry programs and library synthesis in academic and CRO settings.
• Bioconjugation & Probe Development: The reactive chloro group allows for functionalization to create biochemical probes and diagnostic agents.

Basic Information

Product Name	3-Chloro-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	80235-01-4
Molecular Formula	C7H5ClN2
Molecular Weight	152.58 g/mol
Synonyms	3-Chloro-1H-pyrrolo[2,3-b]pyridine; 3-Chloro-7-azaindole; 3-Chloro-1H-pyrrolo[2,3-b]pyridine; 3-Chloro-1H-7-azaindole; 3-Chloro-7-aza-indole; 3-Chloro-1H-pyrrolo(2,3-b)pyridine; 3-Chloro-7-azaindol; 80235-01-4
EINECS	Contact for details

Quality Control

Our 3-Chloro-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.