Description

5-Chloromethyl-Isoxazole-4-Carboxylic Acid Ethyl Ester is a versatile and high-purity chemical building block essential for advanced organic synthesis. Its unique isoxazole core functionalized with a reactive chloromethyl group makes it a critical intermediate for constructing complex heterocyclic molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the isoxazole moiety.
• Material Science Research: Serves as a precursor for developing specialty polymers, ligands, and functional materials with specific electronic or binding properties.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, activity-based probes (ABPs), and other tools for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex, client-specific molecules.

Basic Information

Product Name	5-Chloromethyl-Isoxazole-4-Carboxylic Acid Ethyl Ester
CAS No.	80196-63-0
Molecular Formula	C8H10ClNO3
Molecular Weight	203.62 g/mol
Synonyms	Ethyl 5-(chloromethyl)-1,2-oxazole-4-carboxylate; 4-Carbethoxy-5-chloromethylisoxazole; 5-(Chloromethyl)-4-carbethoxyisoxazole; Ethyl 5-chloromethylisoxazole-4-carboxylate; 5-Chloromethyl-4-ethoxycarbonylisoxazole; Isoxazole-4-carboxylic acid, 5-(chloromethyl)-, ethyl ester; 80196-63-0; AI3-52700
EINECS	Contact for details

Quality Control

Every batch of 5-Chloromethyl-Isoxazole-4-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.