Description

3-Chloro-2-(Chlorocarbonyl)-5-(Trifluoromethyl)Pyridine, also known as 3-Chloro-5-(Trifluoromethyl)Picolinoyl Chloride, is a highly reactive and versatile chemical building block, primarily valued for its role as a key acyl chloride intermediate in advanced organic synthesis. Its molecular structure, featuring both a reactive acid chloride group and a halogenated, fluorinated pyridine ring, makes it indispensable for constructing complex molecules with specific electronic and steric properties. This compound is essential for researchers and manufacturers in the agrochemical and pharmaceutical industries, where it is used to develop novel active ingredients and sophisticated fine chemicals.

Application

• Agrochemical Intermediate: A critical precursor in the synthesis of next-generation herbicides, insecticides, and fungicides, leveraging the trifluoromethylpyridine moiety for enhanced bioactivity and environmental stability.
• Pharmaceutical Building Block: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for creating molecules with improved metabolic stability and binding affinity.
• Ligand Synthesis: Serves as a starting material for synthesizing specialized ligands used in catalysis and material science.
• Functional Material Development: Employed in the creation of advanced organic materials, such as liquid crystals or electronic chemicals, where its specific halogen and fluorine substitution patterns are beneficial.
• Custom Synthesis & Contract Manufacturing: A key reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Chloro-2-(Chlorocarbonyl)-5-(Trifluoromethyl)Pyridine / 3-Chloro-5-(Trifluoromethyl)Picolinoyl Chloride
CAS No.	80194-72-5
Molecular Formula	C7H2Cl2F3NO
Molecular Weight	243.00 g/mol
Synonyms	3-Chloro-5-(trifluoromethyl)picolinoyl chloride; 3-Chloro-5-(trifluoromethyl)pyridine-2-carbonyl chloride; 2-Pyridinecarbonyl chloride, 3-chloro-5-(trifluoromethyl)-; 3-Chloro-5-trifluoromethylpicolinoyl chloride; 3-Chloro-5-trifluoromethyl-2-pyridinecarbonyl chloride; Picolinoyl chloride, 3-chloro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-5-(Trifluoromethyl)Picolinoyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.