Description

3-Fluoro-5-Trifluoromethyl-Pyridine-2-Carbonitrile is a high-value, multi-functional heterocyclic building block characterized by its pyridine core substituted with fluorine, trifluoromethyl, and nitrile groups. This compound matters for its unique electronic properties and structural versatility, making it a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced biological activity and physical stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as components for OLEDs or conductive polymers, due to its electron-withdrawing character.
• Fluorinated Building Block: Provides a versatile scaffold for introducing fluorine atoms into complex molecules, a common strategy in modern medicinal chemistry to fine-tune ADME properties.

Basic Information

Product Name	3-Fluoro-5-Trifluoromethyl-Pyridine-2-Carbonitrile
CAS No.	80194-71-4
Molecular Formula	C7H2F4N2
Molecular Weight	190.10 g/mol
Synonyms	2-Cyano-3-fluoro-5-(trifluoromethyl)pyridine; 3-Fluoro-5-(trifluoromethyl)picolinonitrile; 3-Fluoro-5-trifluoromethyl-2-pyridinecarbonitrile; 5-(Trifluoromethyl)-3-fluoropyridine-2-carbonitrile; 2-Pyridinecarbonitrile, 3-fluoro-5-(trifluoromethyl)-; 80194-71-4; 3-Fluoro-5-trifluoromethylpicolinonitrile
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-Trifluoromethyl-Pyridine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.