Description

3-Chloro-5-(Trifluoromethyl)Pyridine-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a carboxylic acid handle, a chloro substituent, and a highly stable trifluoromethyl group, enabling precise molecular construction. This compound is critically needed by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, inflammation, and infectious diseases.
• Agrochemical Synthesis: Serves as a critical building block for developing next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Used to create sophisticated pyridine-based ligands for transition metal catalysis, enabling more efficient and selective chemical transformations.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with tailored electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of complex molecules under cGMP conditions.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethyl)Pyridine-2-Carboxylic Acid
CAS No.	80194-68-9
Molecular Formula	C7H3ClF3NO2
Molecular Weight	225.55 g/mol
Synonyms	2-Pyridinecarboxylic acid, 3-chloro-5-(trifluoromethyl)-; 3-Chloro-5-(trifluoromethyl)picolinic acid; 3-Chloro-5-trifluoromethylpyridine-2-carboxylic acid; 3-Chloro-5-trifluoromethyl-2-pyridinecarboxylic acid; 3-Chloro-5-(trifluoromethyl)-2-pyridinecarboxylic acid; 80194-68-9; Picolinic acid, 3-chloro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-(Trifluoromethyl)Pyridine-2-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation, including a detailed Certificate of Analysis (COA) with results from HPLC, NMR, and GC-MS to verify identity, purity, and impurity profiles. Our quality commitment ensures material consistency and traceability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.