Description

2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Phenol is a specialized organosilicon-protected phenol derivative, serving as a critical intermediate in advanced organic synthesis. Its primary value lies in its role as a protecting group for phenolic hydroxyl functions, enabling selective reactions in complex multi-step syntheses. This compound is essential for research and production in pharmaceutical development and fine chemical manufacturing, where precise molecular control is paramount.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly where phenolic OH groups require temporary protection.
• Peptide & Natural Product Synthesis: Used to protect tyrosine and other phenolic amino acid derivatives during solid-phase and solution-phase peptide synthesis.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and plant growth regulators with phenolic components.
• Material Science & Polymer Chemistry: Monomer or modifier for creating specialized silicon-containing polymers and advanced materials.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and catalysis studies.
• Fine Chemical Production: Used in the custom synthesis of dyes, fragrances, and other high-value specialty chemicals.

Basic Information

Item	Details
Product Name	2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Phenol
CAS No.	80180-46-7
Molecular Formula	C₁₂H₂₀O₂Si
Molecular Weight	224.37 g/mol
Synonyms	2-[(tert-Butyldimethylsilyl)oxy]phenol; 2-(TBDMSO)Phenol; Phenol, 2-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 2-Hydroxyphenyl tert-butyldimethylsilyl ether; 2-TBDMS-Phenol; o-(tert-Butyldimethylsilyloxy)phenol; 2-(tert-Butyldimethylsiloxy)phenol; TBDMS Protected Catechol
EINECS	Contact for details

Quality Control

Every batch of 2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Phenol is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure the material meets the precise requirements of your synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all commercial quantities, supporting compliance in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.