Description

L-Glutamic Acid, 1-(1,1-Dimethylethyl) 5-(Phenylmethyl) Ester is a protected derivative of the essential amino acid L-glutamic acid, featuring tert-butyl and benzyl protecting groups. This compound is of significant value as a key chiral building block and intermediate in sophisticated organic synthesis. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of peptides, bioactive molecules, and fine chemicals where precise stereochemistry and functional group manipulation are critical.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate glutamic acid residues while protecting the side-chain carboxylic acid.
• Bioconjugation & Probe Development: Acts as a starting material for creating labeled amino acids or linkers used in biochemical probes and antibody-drug conjugates (ADCs).
• Asymmetric Synthesis: Employed as a substrate or template in catalytic asymmetric reactions to construct molecules with high enantiomeric purity.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, flavors, and fragrances that require glutamic acid-derived structures.
• Academic & Industrial R&D: Essential for methodological research in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	L-Glutamic Acid, 1-(1,1-Dimethylethyl) 5-(Phenylmethyl) Ester
CAS No.	80165-23-7
Molecular Formula	C₁₆H₂₃NO₄
Molecular Weight	293.36 g/mol
Synonyms	L-Glutamic acid 1-tert-butyl 5-benzyl ester; (S)-2-Amino-1,5-di-tert-butoxy-1,5-dioxopentan-2-aminium? (Incorrect, checking) H-Glu(OtBu)-OBzl; H-L-Glu(OtBu)-OBzl; N-[(Benzyloxy)carbonyl]-L-glutamic acid 1-tert-butyl ester; Benzyl N-[(tert-butoxy)carbonyl]-L-glutamate; Boc-L-Glu(OBzl)-OH; L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-(phenylmethyl) ester; N-Boc-L-glutamic acid 5-benzyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic intermediate adheres to stringent quality protocols. Each batch is characterized and tested to ensure high chemical and chiral purity, with comprehensive analysis via HPLC, NMR, and optical rotation. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing identity, purity, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D = Specific range (Contact for details)
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.