Description

(E)-4-Methoxy-1-Trimethylsilanyloxy-But-3-En-2-One is a versatile silyl enol ether derivative, a key building block in advanced organic synthesis. Its value lies in its role as a protected enolate equivalent, enabling controlled carbon-carbon bond formation under mild conditions. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of complex molecules, natural products, and novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Aldol Reaction Precursor: Serves as a stable, regioselective enolate equivalent for controlled aldol and related condensation reactions.
• Natural Product Synthesis: Used in the construction of challenging carbon skeletons found in natural products and bioactive compounds.
• Methodology Development: A valuable reagent for chemists developing new synthetic methodologies and catalytic processes.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high-purity intermediates.
• Academic & Industrial R&D: A staple in research laboratories for exploring new chemical spaces and reaction pathways.

Basic Information

Product Name	(E)-4-Methoxy-1-Trimethylsilanyloxy-But-3-En-2-One
CAS No.	80127-63-5
Molecular Formula	C10H20O3Si
Molecular Weight	216.35 g/mol
Synonyms	1-[(1E)-3-Methoxy-1-oxo-2-buten-1-yl]oxy-1,1,1-trimethylsilane; (E)-4-Methoxy-1-(trimethylsiloxy)-2-buten-1-one; 4-Methoxy-1-(trimethylsiloxy)-1-buten-3-one; (E)-4-Methoxy-1-(trimethylsilyloxy)-2-buten-1-one; 3-Buten-2-one, 4-methoxy-1-[(trimethylsilyl)oxy]-, (1E)-; Silyl Enol Ether of 4-Methoxy-3-buten-2-one; TMS enol ether of 4-methoxy-3-buten-2-one
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity synthetic intermediates. Every batch is characterized using advanced analytical techniques including GC, HPLC, and NMR to confirm identity, purity, and isomeric composition. Certificates of Analysis (COA) detailing all specifications are available upon request, providing full traceability and supporting your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Isomeric Purity ((E)-isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.