Description

3-Pyridinemethanol, 6-Chloro-α-(4-Fluorophenyl)- is a high-value pharmaceutical intermediate characterized by its substituted pyridine and fluorinated phenyl structure. This compound is critical for the synthesis of advanced active pharmaceutical ingredients (APIs) and fine chemicals, where its specific molecular architecture imparts desired biological activity and physicochemical properties. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new therapeutic agents and high-performance materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, leveraging its halogenated structure for enhanced bioactivity.
• Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis and organometallic chemistry.
• Material Science: Incorporated into the development of specialty polymers and advanced organic electronic materials.
• Chemical Biology: Employed as a molecular probe or scaffold in medicinal chemistry and biochemical research.

Basic Information

Item	Details
Product Name	3-Pyridinemethanol, 6-Chloro-α-(4-Fluorophenyl)-
CAS No.	80100-31-8
Molecular Formula	C12H9ClFNO
Molecular Weight	237.66 g/mol
Synonyms	6-Chloro-α-(4-fluorophenyl)-3-pyridinemethanol; (6-Chloro-3-pyridinyl)(4-fluorophenyl)methanol; α-(4-Fluorophenyl)-6-chloro-3-pyridinemethanol; (4-Fluorophenyl)(6-chloro-3-pyridinyl)methanol; 6-Chloro-α-(p-fluorophenyl)-3-pyridinemethanol; 80100-31-8; (6-Chloro-pyridin-3-yl)-(4-fluoro-phenyl)-methanol
EINECS	Contact for details

Quality Control

Our production of 3-Pyridinemethanol, 6-Chloro-α-(4-Fluorophenyl)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is manufactured under cGMP-like conditions suitable for pharmaceutical intermediate applications, with comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles against agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.