Description

4-Methyl-5-(4-Fluorophenoxy)Primaquine is a key pharmaceutical intermediate and a structural analog of the antimalarial drug primaquine. This compound is of significant interest in medicinal chemistry for the research and development of novel antiparasitic and antiviral agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel primaquine analogs and related 8-aminoquinoline derivatives for antimalarial research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize pharmacological properties such as efficacy and metabolic stability.
• API Development: Serves as a precursor in the development and scale-up processes for new active pharmaceutical ingredients targeting parasitic diseases.
• Biochemical Research: Employed as a reference standard or probe compound in biochemical assays to study parasite biology and drug mechanisms of action.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing specialized, high-value chemical entities.

Basic Information

Product Name	4-Methyl-5-(4-Fluorophenoxy)Primaquine
CAS No.	80061-25-2
Molecular Formula	C17H19FN2O
Molecular Weight	286.35 g/mol
Synonyms	4-Methyl-5-(p-fluorophenoxy)primaquine; 5-(4-Fluorophenoxy)-6-methoxy-8-[(4-methyl-1-piperazinyl)amino]quinoline; N4-(6-Methoxy-8-quinolinyl)-1-methyl-1,4-piperazinediamine, 5-(4-fluorophenoxy) derivative; Primaquine analog, 4-methyl-5-(4-fluorophenoxy)-; 8-[(4-Methyl-1-piperazinyl)amino]-5-(4-fluorophenoxy)-6-methoxyquinoline; 4-Methyl-5-(4-fluorophenoxy)-primaquine; 80061-25-2
EINECS	Contact for details

Quality Control

Our 4-Methyl-5-(4-Fluorophenoxy)Primaquine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.