Description

4-(Trimethylsilyl)Anisole is a versatile organosilicon compound featuring a trimethylsilyl group attached to an anisole moiety, making it a valuable reagent in advanced synthetic chemistry. Its primary value lies in its role as a protected intermediate and a silylating agent, enabling precise molecular construction in sensitive applications. This product is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring selective deprotection strategies.
• Agrochemical Synthesis: Used in the development and production of advanced pesticides and herbicides where the silyl group acts as a temporary protecting group for phenolic hydroxyl functions.
• Liquid Crystal & OLED Material Precursor: Serves as a fundamental building block in the synthesis of organic semiconductors and liquid crystal molecules for display technologies.
• Silylating Agent: Employed to introduce the trimethylsilyl (TMS) group into organic molecules, altering solubility and volatility for analytical or synthetic purposes.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions, such as the Hiyama coupling, for forming carbon-carbon bonds.
• Fragrance & Flavor Chemistry: Utilized in the synthesis of complex aromatic compounds for specialty fragrance and flavor applications.

Basic Information

Product Name	4-(Trimethylsilyl)Anisole
CAS No.	877-68-9
Molecular Formula	C10H16OSi
Molecular Weight	180.32 g/mol
Synonyms	p-(Trimethylsilyl)anisole; 4-Methoxyphenyltrimethylsilane; Anisole, 4-(trimethylsilyl)-; Trimethyl(4-methoxyphenyl)silane; 1-Methoxy-4-(trimethylsilyl)benzene; NSC 163090; p-Anisyltrimethylsilane
EINECS	212-896-5

Quality Control

Our 4-(Trimethylsilyl)Anisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.495 - 1.505
Density (g/mL, 20°C)	0.92 - 0.96

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.