Description

Triethyl Phosphonoacetate is a versatile organophosphorus compound widely used as a key reagent in organic synthesis. Its primary value lies in its role as a stable phosphonate anion equivalent, enabling the efficient construction of carbon-carbon double bonds via the Horner-Wadsworth-Emmons (HWE) olefination reaction. This makes it an indispensable building block for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to synthesize complex molecules, including α,β-unsaturated esters, with high stereoselectivity.

Application

• Pharmaceutical Intermediates: Critical reagent for synthesizing active pharmaceutical ingredients (APIs), particularly those containing α,β-unsaturated carbonyl moieties.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require specific alkene structures.
• Fine Chemical Manufacturing: Serves as a key precursor for flavors, fragrances, and advanced material monomers.
• Horner-Wadsworth-Emmons Olefination: The premier application, offering advantages over other methods like the Wittig reaction, including easier purification and often better (E)-selectivity.
• Academic & R&D Laboratories: A staple reagent for synthetic organic chemistry research, enabling novel route development and methodology studies.
• Peptide Mimetics & Drug Discovery: Employed in the synthesis of phosphonate-based bioisosteres and other complex molecular architectures.

Basic Information

Product Name	Triethyl Phosphonoacetate
CAS No.	867-13-0
Molecular Formula	C8H17O5P
Molecular Weight	224.19 g/mol
Synonyms	(Triethoxyphosphoryl)acetic Acid Ethyl Ester; Ethyl (Diethoxyphosphinyl)acetate; Diethyl (Ethoxycarbonylmethyl)phosphonate; Acetic Acid, Phosphono-, Triethyl Ester; Triethyl (Carboxymethyl)phosphonate; TEPA; Phosphonoacetic Acid Triethyl Ester
EINECS	212-754-0

Quality Control

Our Triethyl Phosphonoacetate is produced under stringent quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.432 - 1.436
Density (20°C)	1.120 - 1.130 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.