Description

Ethyl 4-Nitrobenzoylacetate is a versatile organic ester compound, serving as a key synthetic intermediate in fine chemical and pharmaceutical manufacturing. Its value lies in the reactive nitro and carbonyl groups, which allow for precise chemical transformations to build complex molecular architectures. This product is essential for research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients or advanced materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of various active pharmaceutical ingredients (APIs), particularly those containing benzodiazepine or other fused heterocyclic ring systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that require specific nitroaromatic motifs.
• Dye and Pigment Manufacturing: Acts as a precursor in the synthesis of azo dyes and other complex colorants, leveraging the nitro group for chromophore development.
• Organic Synthesis Research: Employed in academic and industrial R&D for studying Claisen condensation reactions, Michael additions, and other carbonyl chemistry.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chelating ligands used in catalytic systems.
• Polymer Modification: Can be incorporated as a functional monomer to introduce nitro-aromatic properties into specialty polymer chains.

Basic Information

Product Name	Ethyl 4-Nitrobenzoylacetate
CAS No.	838-57-3
Molecular Formula	C11H11NO5
Molecular Weight	237.21 g/mol
Synonyms	Ethyl (4-Nitrobenzoyl)acetate; 4-Nitrobenzoylacetic Acid Ethyl Ester; Ethyl 4-Nitrobenzoylacetate; Acetic acid, 2-(4-nitrobenzoyl)-, ethyl ester; Ethyl 3-oxo-3-(4-nitrophenyl)propanoate; 3-(4-Nitrophenyl)-3-oxopropanoic acid ethyl ester; NSC 404080; Ethyl p-nitrobenzoylacetate
EINECS	212-647-6

Quality Control

Every batch of Ethyl 4-Nitrobenzoylacetate is produced and tested under a strict quality management system to ensure consistency and reliability for your synthetic processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity, identity, and impurity profiles. Our standard grade meets the rigorous demands of industrial-scale organic synthesis, and we can discuss custom purity specifications or analytical methods to align with your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light) and should be handled in a manner that minimizes prolonged exposure to air and moisture to maintain stability.

Specification

Item	Specification
Appearance	Yellow to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.