Description

N-(2,2,2-Trifluoroethyl)Urea is a specialized fluorinated urea derivative, a high-value building block in advanced organic synthesis. Its core value lies in introducing the trifluoroethyl pharmacophore, which can significantly alter the metabolic stability, lipophilicity, and bioavailability of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the trifluoroethyl group can enhance biological activity and environmental persistence profiles.
• Fluorinated Compound Library Development: Serves as a valuable reagent for constructing diverse fluorinated compound libraries for high-throughput screening in drug discovery.
• Material Science Research: Investigated as a monomer or modifying agent in the development of specialty polymers with unique surface properties, chemical resistance, or optical characteristics.
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes to study enzyme mechanisms or biological pathways where fluorine acts as a spectroscopic or isotopic label.

Basic Information

Product Name	N-(2,2,2-Trifluoroethyl)Urea
CAS No.	819-60-3
Molecular Formula	C3H5F3N2O
Molecular Weight	142.08 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)urea; Urea, N-(2,2,2-trifluoroethyl)-; 2,2,2-Trifluoroethylurea; (2,2,2-Trifluoroethyl)urea; N-(Trifluoroethyl)urea; Trifluoroethylurea; 819-60-3; AI3-52255; NSC 401070; EINECS 212-473-8
EINECS	212-473-8

Quality Control

Our N-(2,2,2-Trifluoroethyl)Urea is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.