Description

Tetrahydro-2-(2,2,2-trifluoroethoxy)-2H-pyran is a specialized fluorinated heterocyclic compound that serves as a valuable building block in advanced organic synthesis. Its unique structure, featuring a tetrahydropyran ring ether-linked to a trifluoroethoxy group, makes it a versatile intermediate for introducing fluorine-containing motifs into target molecules. This compound is particularly relevant for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to develop novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, potentially in antiviral, anti-inflammatory, or CNS-active therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the trifluoroethoxy group can improve lipophilicity and biological activity.
• Liquid Crystal & Electronic Materials: Serves as a precursor in the synthesis of fluorinated components for liquid crystal displays (LCDs) and other specialty electronic materials.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to create fluorinated polymers with specific surface properties, chemical resistance, or low dielectric constants.
• Organic Synthesis & Catalysis Research: A valuable reagent in methodological studies for constructing complex ethers and exploring new fluorination pathways.
• Material Science Additive: Potential use as an additive or surface treatment agent to impart oil- and water-repellent characteristics to materials.

Basic Information

Product Name	Tetrahydro-2-(2,2,2-trifluoroethoxy)-2H-pyran
CAS No.	16408-83-6
Molecular Formula	C7H11F3O2
Molecular Weight	184.16 g/mol
Synonyms	2-(2,2,2-Trifluoroethoxy)tetrahydro-2H-pyran; 2H-Pyran, tetrahydro-2-(2,2,2-trifluoroethoxy)-; 2-Trifluoroethoxytetrahydropyran; α-Trifluoroethoxytetrahydro-2H-pyran; Tetrahydro-2-(trifluoroethoxy)-2H-pyran; 2-(Trifluoroethoxy)tetrahydropyran; 2-Tetrahydropyranyl 2,2,2-trifluoroethyl ether
EINECS	Contact for details

Quality Control

Our Tetrahydro-2-(2,2,2-trifluoroethoxy)-2H-pyran is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and industrial synthesis. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and physical properties is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.390 - 1.400
Density (20°C)	1.20 - 1.30 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.