Description

2,2-Difluoroethyl Acetate is a versatile fluorinated ester building block with significant utility in advanced chemical synthesis. Its value lies in its ability to introduce the difluoroethyl moiety, a key structural feature that can enhance the metabolic stability, lipophilicity, and bioavailability of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries, as well as by fine chemical manufacturers engaged in producing specialty intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated side chains for improved drug-like properties.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where fluorine incorporation can increase efficacy and environmental persistence.
• Liquid Crystal & Electronic Chemicals: Serves as a fluorinated building block for materials used in display technologies and specialty coatings.
• Organic Synthesis Reagent: Employed in various reactions, including esterifications and transesterifications, to introduce fluorinated groups into complex organic frameworks.
• Polymer Modification: Acts as a monomer or modifier to impart unique properties like chemical resistance or altered surface energy to polymeric materials.
• Solvent for Specialty Applications: Its properties as a highly volatile and polar aprotic solvent make it suitable for specific reaction media or formulation processes in R&D.

Basic Information

Product Name	2,2-Difluoroethyl Acetate
CAS No.	1550-44-3
Molecular Formula	C4H6F2O2
Molecular Weight	124.09 g/mol
Synonyms	Acetic Acid 2,2-Difluoroethyl Ester; 2,2-Difluoroethanol Acetate; 1,1-Difluoro-2-acetoxyethane; Ethanol, 2,2-difluoro-, acetate; 2,2-Difluoroethyl ethanoate; DFEA; EINECS 216-286-5
EINECS	216-286-5

Quality Control

Our 2,2-Difluoroethyl Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids, bases, and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Density (20°C)	1.20 - 1.25 g/mL
Refractive Index (20°C)	1.355 - 1.365

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.