Description

n-(Trifluoroacetyl)-L-Glutamic Acid Dibutyl Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound is valued for its role as a key chiral building block and protecting group intermediate in the development of complex molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for peptide synthesis and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of peptide-based drugs and complex bioactive molecules.
• Peptide Chemistry: Serves as a protected glutamic acid derivative for solid-phase and solution-phase peptide synthesis.
• Agrochemical Research: Used in the development of novel herbicides and pesticides with specific chiral activity.
• Bioconjugation: Acts as a reagent for modifying proteins and other biomolecules via its reactive ester and protected amine functionalities.
• Chemical Biology Probes: Employed in the creation of labeled compounds and probes for studying biological pathways.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs producing custom fine chemicals.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Glutamic Acid Dibutyl Ester
CAS No.	816-59-1
Molecular Formula	C15H24F3NO5
Molecular Weight	355.35 g/mol
Synonyms	L-Glutamic Acid, N-(Trifluoroacetyl)-, Dibutyl Ester; Dibutyl N-(Trifluoroacetyl)-L-glutamate; N-Trifluoroacetyl-L-glutamic Acid Dibutyl Ester; (S)-2-(2,2,2-Trifluoroacetamido)pentanedioic Acid Dibutyl Ester; N-TFA-L-Glutamic Acid Dibutyl Ester; N-(Trifluoroacetyl)glutamic Acid Dibutyl Ester; 816-59-1; FC-1313
EINECS	212-425-8

Quality Control

Our n-(Trifluoroacetyl)-L-Glutamic Acid Dibutyl Ester is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and production applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee consistent quality, identity, and purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.