Description

(2R,5R)-5-Hydroxy-1,2-Piperidinedicarboxylic Acid 2-Methyl 1-Benzyl Ester CAS NO 797801-68-4 is a high-purity, stereochemically defined chiral piperidine derivative. This compound serves as a critical advanced pharmaceutical intermediate and a versatile chiral building block for the synthesis of complex bioactive molecules. It is essential for research and development in the pharmaceutical industry, particularly for medicinal chemists and process development scientists working on neurological and metabolic drug candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of potent protease inhibitors and other active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a constrained scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Serves as a precursor or auxiliary for constructing complex molecules with high enantiomeric purity.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying enzyme mechanisms and biological pathways.
• Process Chemistry Development: Employed in route scouting and scale-up optimization for the commercial manufacturing of chiral drugs.

Basic Information

Product Name	(2R,5R)-5-Hydroxy-1,2-Piperidinedicarboxylic Acid 2-Methyl 1-Benzyl Ester
CAS No.	797801-68-4
Molecular Formula	C16H21NO5
Molecular Weight	307.34 g/mol
Synonyms	5-Hydroxypipecolic Acid 2-Methyl 1-Benzyl Ester; (2R,5R)-5-Hydroxypipecolic Acid Methyl Benzyl Ester; 1-Benzyl 2-Methyl (2R,5R)-5-Hydroxy-1,2-piperidinedicarboxylate; (2R,5R)-1-Benzyl 2-Methyl 5-Hydroxypiperidine-1,2-dicarboxylate; Methyl Benzyl (2R,5R)-5-Hydroxypipecolate; (2R,5R)-5-Hydroxy-N-benzyl-N-methylpipecolamide Derivative
EINECS	Contact for details

Quality Control

Our (2R,5R)-5-Hydroxy-1,2-Piperidinedicarboxylic Acid 2-Methyl 1-Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for advanced research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.