Description

tert-Butyl 4-Hydroxytetrahydrofuran-3-Carboxylate is a versatile chiral building block and protected hydroxy acid derivative of significant value in advanced organic synthesis. Its structure, featuring both a hydroxyl group and a tert-butyl ester, makes it a critical intermediate for constructing complex molecules with precise stereochemistry. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of complex drug candidates and bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides requiring specific stereochemical configurations.
• Fine Chemical Production: Serves as a precursor for flavors, fragrances, and other high-value specialty chemicals.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry, particularly in studies involving ring-opening, esterification, and protection/deprotection strategies.
• Peptidomimetics & Prodrug Design: The protected carboxylate and hydroxyl functionalities are useful in designing peptide analogs and prodrug linkers.

Basic Information

Product Name	tert-Butyl 4-Hydroxytetrahydrofuran-3-Carboxylate
CAS No.	797038-33-6
Molecular Formula	C9H16O4
Molecular Weight	188.22 g/mol
Synonyms	3-Furancarboxylic acid, 4-hydroxy-tetrahydro-, 1,1-dimethylethyl ester; 4-Hydroxytetrahydrofuran-3-carboxylic acid tert-butyl ester; tert-Butyl 4-hydroxyoxolane-3-carboxylate; (R/S)-tert-Butyl 4-hydroxytetrahydrofuran-3-carboxylate; Oxolane-3-carboxylic acid, 4-hydroxy-, 1,1-dimethylethyl ester; TBHTFC; 797038-33-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Hydroxytetrahydrofuran-3-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area Percent)
Chiral Purity (Chiral HPLC)	≥99.0% ee (for enantiopure grades)
Water Content (KF)	≤0.5% w/w
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.