Description

1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-Ethyl 5-[2-(4-Methyl-1-Piperazinyl)Ethyl] Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological pathways. It is essential for pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the synthesis of complex, small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel dihydropyridine-based calcium channel blockers and other therapeutic agents.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new chemical entities.
• Process Chemistry: Serves as a key intermediate in the scale-up and optimization of API manufacturing processes under GMP conditions.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Chemical Synthesis: Utilized in organic synthesis for constructing complex molecular architectures containing dihydropyridine and piperazine moieties.

Basic Information

Product Name	1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-Ethyl 5-[2-(4-Methyl-1-Piperazinyl)Ethyl] Ester
CAS No.	797013-83-3
Molecular Formula	C24H30N4O6
Molecular Weight	470.52 g/mol
Synonyms	3-Ethyl 5-[2-(4-Methylpiperazin-1-yl)ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl 5-[2-(4-methyl-1-piperazinyl)ethyl] ester; Lercanidipine Intermediate; Lercanidipine Related Compound; Dihydropyridine Ester Derivative; CAS 797013-83-3
EINECS	Contact for details

Quality Control

Our 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-Ethyl 5-[2-(4-Methyl-1-Piperazinyl)Ethyl] Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with ICH guidelines and customer-specific requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.