Description

n-Boc-4-Iodo-Dl-Phenylalanine Methyl Ester is a protected, iodinated derivative of the amino acid phenylalanine, serving as a versatile and crucial building block in advanced organic synthesis. Its value lies in the orthogonal protection of the amine group by the Boc moiety and the reactive iodine handle on the aromatic ring, enabling precise, sequential chemical modifications. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and complex bioactive molecules, particularly for structure-activity relationship (SAR) studies and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel peptide-based therapeutics and drug candidates.
• Medicinal Chemistry Research: Used in SAR studies to introduce iodine for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Peptide Synthesis: Serves as a protected, non-natural amino acid derivative for incorporating iodophenylalanine residues into peptide chains.
• Chemical Biology Probes: Foundation for creating labeled peptides or affinity probes for target identification and binding studies.
• Organic Synthesis: Versatile intermediate for constructing complex, iodine-containing organic architectures and fine chemicals.
• Agrochemical Research: Potential intermediate in the development of new active ingredients with specific biological activity.

Basic Information

Product Name	n-Boc-4-Iodo-Dl-Phenylalanine Methyl Ester
CAS No.	796072-33-8
Molecular Formula	C₁₅H₂₀INO₄
Molecular Weight	405.23 g/mol
Synonyms	(±)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(4-iodophenyl)propanoate; DL-4-Iodophenylalanine, N-BOC-, methyl ester; Boc-4-Iodo-DL-Phe-OMe; tert-Butyl (1-methoxy-1-oxo-3-(4-iodophenyl)propan-2-yl)carbamate; Methyl N-(tert-butoxycarbonyl)-4-iodo-DL-phenylalaninate; N-Boc-4-iodo-DL-phenylalanine methyl ester; 4-Iodo-N-Boc-DL-phenylalanine methyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-4-Iodo-Dl-Phenylalanine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.