Description

3H-Cyclopenta[B]Pyridin-2-Amine,4,4A,5,6,7,7A-Hexahydro-4-Methyl-,[4R- is a high-purity, stereochemically defined organic intermediate of significant interest in advanced pharmaceutical synthesis. This compound matters for its role as a key chiral building block in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. Pharmaceutical R&D departments and fine chemical manufacturers need this material for constructing complex molecular architectures where the specific [4R- stereochemistry is critical for biological activity and process optimization.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new drug candidates, especially in neurological and psychiatric therapeutic areas.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring a fused cyclopenta-pyridine amine scaffold.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in studies exploring new asymmetric synthetic methodologies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes in pilot plants and commercial manufacturing settings.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and regulatory filing support.

Basic Information

Product Name	3H-Cyclopenta[B]Pyridin-2-Amine,4,4A,5,6,7,7A-Hexahydro-4-Methyl-,[4R-
CAS No.	793646-33-0
Molecular Formula	C9H16N2
Molecular Weight	152.24 g/mol
Synonyms	(4R)-4-Methyl-4,4a,5,6,7,7a-hexahydro-3H-cyclopenta[b]pyridin-2-amine; 4-Methyl-4,4a,5,6,7,7a-hexahydro-3H-cyclopenta[b]pyridin-2-amine (4R)-; (4R)-4-Methyl-1,4,4a,5,6,7,7a,8-octahydrocyclopenta[b]pyridin-2-amine; 793646-33-0; 4R enantiomer of hexahydrocyclopentapyridinamine; Chiral cyclopentapyridine amine intermediate
EINECS	Contact for details

Quality Control

Our 3H-Cyclopenta[B]Pyridin-2-Amine,4,4A,5,6,7,7A-Hexahydro-4-Methyl-,[4R- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with stringent pharmaceutical-grade specifications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.